Molecular Modeling of Human BAD, a Pro-Apoptotic Bcl-2 Family Member, Integrating Glycolysis and Apoptosis

Author(s): Jie Yang

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 2 , 2010

Become EABM
Become Reviewer


Comparison between the BAD complexes indicated that BAD all docks a hydrophobic surface of PKAc regardless of its phosphorylation. PKAc may prevent Bcl-xL from rebinding to BAD by phosphorylating human BAD at Ser118; whereas human BAD is phosphorylated on Ser75 in a BAD-Bcl-xL complex, resulting in the dissociation of BAD.

Keywords: Computational modeling, protein-protein interaction, sequence alignment

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [206 - 220]
Pages: 15
DOI: 10.2174/092986610790226003
Price: $65

Article Metrics

PDF: 10