Development of Novel Therapeutic Drugs in Humans from Plant Antimicrobial Peptides

Author(s): Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Suely Lins Galdino

Journal Name: Current Protein & Peptide Science

Volume 11 , Issue 3 , 2010

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All living organisms, ranging from microorganisms to plants and mammals, have evolved mechanisms to actively defend themselves against pathogen attack. A wide range of biological activities have been attributed to plant antimicrobial peptides (AMPs) including growth inhibitory effects on a broad range of fungi, Gram-positive and Gram-negative bacteria, viruses, neoplastic cells and parasitic protozoa. Classes of AMPs, their mechanisms of action, biological activity, and cytotoxicity towards host cells are discussed. A particular focus regards AMP candidates with potential for use in defense against biological warfare agents. This field is young, but provides additional stimulus to consideration of these molecules as a new class of therapeutic agents and promises to revolutionize treatment of many infectious diseases.

Keywords: AMPs, novel therapeutic approaches

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Article Details

Year: 2010
Page: [236 - 247]
Pages: 12
DOI: 10.2174/138920310791112066
Price: $65

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PDF: 14