The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.
Keywords: (+)-cis-Diltiazem, L-type calcium channels, benzothiazepine, chemotype, computational approaches, voltage gated calcium channel, calcium entry blockers, structural and functional analogs
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Published on: 01 March, 2012
Page: [1379 - 1388]