The Use of Bevacizumab and Trastuzumab Beyond Tumor Progression: A New Avenue in Cancer Treatment?

Author(s): F. Meriggi, C. Abeni, B. Di Biasi, A. Zaniboni

Journal Name: Reviews on Recent Clinical Trials

Volume 4 , Issue 3 , 2009


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Abstract:

The use of the Monoclonal Antibodies (MoAbs) Bevacizumab (B) and Trastuzumab (T) beyond clinical progression in colorectal and breast cancer treatment is among the hottest topics in todays clinical oncology. Both observational and prospective studies, based on a sound preclinical basis, seem to support the notion that, simply replacing the cytotoxic drugs combined with the two MoAbs would provide an additional clinical benefit without stopping the biological agent. The aim of this review is to provide a critical analysis of the available clinical data, while waiting for the confirmatory prospective clinical trials still ongoing. The strength and the weakness of this innovative strategy, as well as the associated expense and toxicity issues will be discussed.

Keywords: Trastuzumab, bevacizumab, use beyond progression, breast cancer, colon cancer

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2009
Page: [163 - 167]
Pages: 5
DOI: 10.2174/157488709789957682
Price: $65

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