Novel Amphiphilic Hyperbranched Poly (amine-ester) Copolymers Nanoparticles as Protein Drug Delivery

Author(s): Ming Jiang, Tiewei Wang, Qing Xu, Yan Wu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 11 , 2009

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Novel amphiphilic protein-loaded hyperbranched poly (amine-ester) copolymers nanoparticles were fabricated by double emulsion (DE) and nanoprecipitation (NP) methods. Encapsulation efficiency (EE) of nanoparticles to Bovine serum albumin (BSA) could reach 97.8% at BSA (0.01g/ml), internal phase volume (0.5ml), copolymer weight (50mg), and PVA concentration (4%, w/v) condition.

Keywords: Hyperbranched poly (amine-ester), poly(lactide), ring-opening polymerization, nanoaprticles, double emulsion (DE) method, nanoprecipitation (NP) method, bovine serum albumin, protein delivery system

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Article Details

Year: 2009
Page: [1342 - 1356]
Pages: 15
DOI: 10.2174/138955709789878088
Price: $65

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