Amphotericin B: From Derivatives to Covalent Targeted Conjugates

Author(s): Milos Sedlak

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 11 , 2009

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This mini-review summarizes the development of the derivatives and conjugates of Amphotericin B (AMB) which have not been clinically applied so far but are therapeutically promising. Effects of chemical modifications of AMB upon biological activities of the resulting derivatives are discussed. The examples presented include variation of functional groups in AMB, covalent conjugates with other molecules, poly(ethylene glycols) and polysaccharides. Possibilities of targeted delivery of AMB are discussed.

Keywords: Amphotericin B, antimycotics, systemic mycosis, poly(ethylene glycol), polysaccharides, drug targeting, pHsensitivity, β-glucosidase-sensitivity

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Article Details

Year: 2009
Page: [1306 - 1316]
Pages: 11
DOI: 10.2174/138955709789878178
Price: $65

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