Roles of Laminin-332 and α6β4 Integrin in Tumor Progression

Author(s): Y. Kariya, Y Kariya, J. Gu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 11 , 2009

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Laminin-332 and α6β4 integrin is major hemidesmosome components in the skin. As many studies have shown that laminin-332 and α6β4 integrin play important roles in tumor progression via activation of phosphatidylinositol-3 kinase signaling, understanding of the molecular mechanisms of them could lead to a new drug for cancer therapy.

Keywords: Laminin-332, α6β4 integrin, basement membrane, extracellular matrix, tumor, cell migration, cell adhesion, ErbB2

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Article Details

Year: 2009
Page: [1284 - 1291]
Pages: 8
DOI: 10.2174/138955709789878114
Price: $65

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