Inhibitors of HMG-CoA Reductase: Current and Future Prospects

Author(s): Narender Singh, Joaquin Tamariz, German Chamorro, Jose L. Medina-Franco

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 11 , 2009


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Abstract:

High levels of cholesterol are a primary risk factor in the development of cardiovascular diseases. In this review, we have summarized the structural, chemical and computational aspects of hypocholesterolemic drugs, both statins and non-statins, that target enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) to block cholesterol biosynthesis.

Keywords: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, α-asarone, cardiovascular disease, low density lipoproteins, cholesterol, statins, side effects, structure-based drug design

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Article Details

VOLUME: 9
ISSUE: 11
Year: 2009
Page: [1272 - 1283]
Pages: 12
DOI: 10.2174/138955709789878105
Price: $65

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