Homology Modelling of Human E1 Ubiquitin Activating Enzyme

Title: Homology Modelling of Human E1 Ubiquitin Activating Enzyme

Volume: 7 Issue: 1

Author(s): Ghali Brahemi, Angelika M. Burger, Andrew D. Westwell and Andrea Brancale

Affiliation:

Keywords: Ubiquitination, Human E1, Ubiquitin activating enzyme, Homology modelling

Abstract: Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

Cite this article as:

Brahemi Ghali, Burger M. Angelika, Westwell D. Andrew and Brancale Andrea, Homology Modelling of Human E1 Ubiquitin Activating Enzyme, Letters in Drug Design & Discovery 2010; 7 (1) . https://dx.doi.org/10.2174/157018010789869316