Title: Synthesis and Biological Activity of New Triazole Compounds
VOLUME: 7 ISSUE: 1
Author(s):Hanane Al Bay, Bouchra Quaddouri, Abdelkarim Guaadaoui, Rachid Touzani, Nour-Eddine Benchat, Abdellah Hamal, Mustafa Taleb, Mohammed Bellaoui and Sghir El Kadiri
Affiliation:Laboratoire de Chimie Appliquee et Environnement, Departement de Chimie, Faculte des Sciences, Universite Mohamed Premier, BP 524, 60 000 Oujda, Morocco.
Keywords:Synthesis, Antifungal activity, Antibacterial activity, Tridentate ligand, Nitrogen-rich and Triazole
Abstract: Six new N,N-bis(1,2,4-triazol-1-ylmethyl)amines have been prepared in one step by condensation of 1- (hydroxymethyl)triazole with a series of amines. These reactions were carried out in refluxed CH3CN for 4 hours. The products were recuperated with excellent and good yields (75-89.5%). Compounds (3a-f) were screened for their antifungal activity against the budding yeast Saccharomyces cerevisiae and their antibacterial activity against Escherichia coli.
