Synthesis and Biological Activity of New Triazole Compounds

Author(s): Hanane Al Bay, Bouchra Quaddouri, Abdelkarim Guaadaoui, Rachid Touzani, Nour-Eddine Benchat, Abdellah Hamal, Mustafa Taleb, Mohammed Bellaoui, Sghir El Kadiri

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 1 , 2010

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Six new N,N-bis(1,2,4-triazol-1-ylmethyl)amines have been prepared in one step by condensation of 1- (hydroxymethyl)triazole with a series of amines. These reactions were carried out in refluxed CH3CN for 4 hours. The products were recuperated with excellent and good yields (75-89.5%). Compounds (3a-f) were screened for their antifungal activity against the budding yeast Saccharomyces cerevisiae and their antibacterial activity against Escherichia coli.

Keywords: Synthesis, Antifungal activity, Antibacterial activity, Tridentate ligand, Nitrogen-rich and Triazole

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Article Details

Year: 2010
Page: [41 - 45]
Pages: 5
DOI: 10.2174/157018010789869352

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PDF: 37