Synthesis and Preliminary Biological Activity of Some New Pyrazole Derivatives as Acyclonucleoside Analogues

Author(s): Smaail Radi, Souad Salhi, Amal Radi

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 1 , 2010

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Some novel pyrazole acyclonucleosides were prepared through binding of pyrazole-3,5-substituted derivatives with acyclic substituents mimetizing individual fragments of the ribose ring such as: 1-[(2-hydroxyethoxy) methyl], 1-[4-(hydroxybutyl)], 1-[3- (hydroxypropyl)] and 1-[(2-hydroxyethyl amino) methyl]. Their syntheses were performed from easily accessible starting materials. The prepared compounds were evaluated for their antibacterial activity. Structure-activity relationship studies (SAR) indicate that introduction of modified arm in N1 position of pyrazole moieties has not any impact on the biolgical activity.

Keywords: Pyrazole, Acyclonucleoside, Synthesis, Biological activity

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Article Details

Year: 2010
Page: [27 - 30]
Pages: 4
DOI: 10.2174/157018010789869307

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PDF: 33