The Antisense Oligonucleotides Decrease Expression of the Cellular Prion

Author(s): Vitalii V. Stadnyk, Lyudmyla A. Izyumova, Yuriy A. Rzhepetskiy, Chrystyna Ya Mayor, Vasyl V. Vlizlo

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 1 , 2010

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The subject of this work was an inhibition of cellular prion expression in vitro and in vivo by antisense oligodeoxyribonucleotides, incorporated into cationic immunoliposomes. It was shown that asODNs are able to reduce the level of PrPc expression in vitro and in vivo.

Keywords: Cellular prion, Antisense oligodesoxyribonucleotides, Immunoliposomes

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Article Details

Year: 2010
Page: [23 - 26]
Pages: 4
DOI: 10.2174/157018010789869299

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PDF: 11