The Antisense Oligonucleotides Decrease Expression of the Cellular Prion

Vitalii   V.   Stadnyk; Lyudmyla   A.   Izyumova; Yuriy   A.   Rzhepetskiy; Chrystyna   Ya   Mayor; Vasyl   V.   Vlizlo

Author(s): Vitalii V. Stadnyk, Lyudmyla A. Izyumova, Yuriy A. Rzhepetskiy, Chrystyna Ya Mayor and Vasyl V. Vlizlo

Volume 7, Issue 1, 2010

Page: [23 - 26] Pages: 4

DOI: 10.2174/157018010789869299

Price: $65

Abstract

The subject of this work was an inhibition of cellular prion expression in vitro and in vivo by antisense oligodeoxyribonucleotides, incorporated into cationic immunoliposomes. It was shown that asODNs are able to reduce the level of PrPc expression in vitro and in vivo.

Keywords: Cellular prion, Antisense oligodesoxyribonucleotides, Immunoliposomes

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Letters in Drug Design & Discovery

Title: The Antisense Oligonucleotides Decrease Expression of the Cellular Prion

Volume: 7 Issue: 1

Author(s): Vitalii V. Stadnyk, Lyudmyla A. Izyumova, Yuriy A. Rzhepetskiy, Chrystyna Ya Mayor and Vasyl V. Vlizlo

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Keywords: Cellular prion, Antisense oligodesoxyribonucleotides, Immunoliposomes

Abstract: The subject of this work was an inhibition of cellular prion expression in vitro and in vivo by antisense oligodeoxyribonucleotides, incorporated into cationic immunoliposomes. It was shown that asODNs are able to reduce the level of PrPc expression in vitro and in vivo.

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Stadnyk V. Vitalii, Izyumova A. Lyudmyla, Rzhepetskiy A. Yuriy, Mayor Ya Chrystyna and Vlizlo V. Vasyl, The Antisense Oligonucleotides Decrease Expression of the Cellular Prion, Letters in Drug Design & Discovery 2010; 7 (1) . https://dx.doi.org/10.2174/157018010789869299