Title: Structure Activity Relationship of Organic Alcohol and Esters for Antidepressant- Like Activity
VOLUME: 7 ISSUE: 1
Author(s):Shahnaz Perveen, Arfa Yasmeen, Muhammad Aitmaud Khan, Ahsana Dar, Rehana Jafri and Amir Ahmed
Affiliation:PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi-75280, Pakistan.
Keywords:Alcohol, Esters, Antidepressant, Forced Swim Test
Abstract: The synthesized compounds 1-7 were evaluated for their antidepressant activity, among which 2-phenylethyl alcohol 1 and isoamyl phenylacetate 3 showed 43 % and 37 % reduction in immobility time in mice using forced swim test, thereby, displaying antidepressant- like activity. Compound 1 and 3 were equipotent and both these compounds were 2x effective than the standard drug phenelzine. Considering other esters it appears that a decrease in alkyl chain length or addition of either NO2 or OH groups to the phenyl ring caused a marked decline in the antidepressant-like activity.
