Structure Activity Relationship of Organic Alcohol and Esters for Antidepressant- Like Activity

Author(s): Shahnaz Perveen, Arfa Yasmeen, Muhammad Aitmaud Khan, Ahsana Dar, Rehana Jafri, Amir Ahmed

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 1 , 2010

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The synthesized compounds 1-7 were evaluated for their antidepressant activity, among which 2-phenylethyl alcohol 1 and isoamyl phenylacetate 3 showed 43 % and 37 % reduction in immobility time in mice using forced swim test, thereby, displaying antidepressant- like activity. Compound 1 and 3 were equipotent and both these compounds were 2x effective than the standard drug phenelzine. Considering other esters it appears that a decrease in alkyl chain length or addition of either NO2 or OH groups to the phenyl ring caused a marked decline in the antidepressant-like activity.

Keywords: Alcohol, Esters, Antidepressant, Forced Swim Test

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Article Details

Year: 2010
Page: [14 - 17]
Pages: 4
DOI: 10.2174/157018010789869334

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PDF: 60