Design, Synthesis, and Biological Evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Acetylcholinesterase Inhibitors

Title: Design, Synthesis, and Biological Evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Acetylcholinesterase Inhibitors

Volume: 7 Issue: 1

Author(s): Si-Jie Liu, Liu Yang, Xiao-Guang Liu, Ying Luo, Zi-Jian Cao, David Chi Cheong Wan, Huang-Quan Lin and Chun Hu

Affiliation:

Keywords: Acetylcholinesterase, Inhibitors, Synthesis, Heterocycles, Docking, 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivative

Abstract: The docking study on a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives with acetylcholinesterase has been demonstrated. The synthesis and characterization of a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were described. All target compounds were evaluated in vitro for the inhibitory activities against AChE via Ellman colorimetric assay. Most of the target compounds possessed anti-acetylcholinesterase activity. The preliminary structure-activity relationships were discussed.

Cite this article as:

Liu Si-Jie, Yang Liu, Liu Xiao-Guang, Luo Ying, Cao Zi-Jian, Cheong Wan Chi David, Lin Huang-Quan and Hu Chun, Design, Synthesis, and Biological Evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Acetylcholinesterase Inhibitors, Letters in Drug Design & Discovery 2010; 7 (1) . https://dx.doi.org/10.2174/157018010789869343