Diabetes and Antioxidants: Myth or Reality?

Author(s): Mohamed A. Haidara, Hanaa Z. Yassin, Zorica Zakula, Dimitri P. Mikhailidis, Esma R. Isenovic

Journal Name: Current Vascular Pharmacology

Volume 8 , Issue 5 , 2010

Become EABM
Become Reviewer
Call for Editor


Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies.

Keywords: Diabetes, oxidative stress, antioxidants, statins

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [661 - 672]
Pages: 12
DOI: 10.2174/157016110792006941
Price: $65

Article Metrics

PDF: 11