Abstract
Alzheimers disease (AD) prominently affects the structure and function of cerebral networks. Reflecting the complex network structure of the brain, spontaneous brain activity is organized by synchronized activity across distinct temporal and spatial scales. Temporal correlations of the functional MRI (fMRI) signal during rest have been used to characterize the impact of AD on the functional connectivity of spontaneous brain activity. Here we review studies using resting-state fMRI (rs-fMRI) to explore AD-induced changes of synchronized intrinsic activity at three levels of brain organization: the regional, inter-regional and large-scale level. Changes in posterior areas of the default network (DN) and the medial temporal lobes seem to be central to AD. These areas show remarkable disturbances in neuronal communication at all spatial levels and in very early stages of the disease. Finally, rs-fMRI seems to have the potential to produce connectivity-related biomarkers that distinguish AD and healthy aging.
Keywords: Alzheimer's disease, spontaneous brain activity, functional connectivity, fMRI, resting state, resting state networks, small world, local integration
Current Alzheimer Research
Title: Impact of Alzheimers Disease on the Functional Connectivity of Spontaneous Brain Activity
Volume: 6 Issue: 6
Author(s): Christian Sorg, Valentin Riedl, Robert Perneczky, Alexander Kurz and Afra M. Wohlschlager
Affiliation:
Keywords: Alzheimer's disease, spontaneous brain activity, functional connectivity, fMRI, resting state, resting state networks, small world, local integration
Abstract: Alzheimers disease (AD) prominently affects the structure and function of cerebral networks. Reflecting the complex network structure of the brain, spontaneous brain activity is organized by synchronized activity across distinct temporal and spatial scales. Temporal correlations of the functional MRI (fMRI) signal during rest have been used to characterize the impact of AD on the functional connectivity of spontaneous brain activity. Here we review studies using resting-state fMRI (rs-fMRI) to explore AD-induced changes of synchronized intrinsic activity at three levels of brain organization: the regional, inter-regional and large-scale level. Changes in posterior areas of the default network (DN) and the medial temporal lobes seem to be central to AD. These areas show remarkable disturbances in neuronal communication at all spatial levels and in very early stages of the disease. Finally, rs-fMRI seems to have the potential to produce connectivity-related biomarkers that distinguish AD and healthy aging.
Export Options
About this article
Cite this article as:
Sorg Christian, Riedl Valentin, Perneczky Robert, Kurz Alexander and Wohlschlager M. Afra, Impact of Alzheimers Disease on the Functional Connectivity of Spontaneous Brain Activity, Current Alzheimer Research 2009; 6 (6) . https://dx.doi.org/10.2174/156720509790147106
DOI https://dx.doi.org/10.2174/156720509790147106 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Plasma Steroid Level Measured Using Modern Separation Techniques as Biomarkers in Biological Diagnostics
Current Pharmaceutical Analysis ES-MDA: Enhanced Similarity-based MiRNA-Disease Association
Current Protein & Peptide Science Absorption, Disposition and Pharmacokinetics of Nanoemulsions
Current Drug Metabolism Hypoxia and Fetal Heart Development
Current Molecular Medicine Opioid Transport by ATP-Binding Cassette Transporters at the Blood-Brain Barrier: Implications for Neuropsychopharmacology
Current Pharmaceutical Design Is Helicobacter pylori Always a "Bad Guy"?
Current Pharmaceutical Design Neurological Disorders in Medical Use of <i>Cannabis</i>: An Update
CNS & Neurological Disorders - Drug Targets Adverse Drug Reactions in Critical Care Settings: A Systematic Review
Current Drug Safety KSP Inhibitors as Antimitotic Agents
Current Topics in Medicinal Chemistry The Role of Toll-Like Receptors and Type I Interferons in Host Responses to Bacteria
Current Immunology Reviews (Discontinued) Stem Cell and Idiopathic Pulmonary Fibrosis: Mechanisms and Treatment
Current Stem Cell Research & Therapy AAV-Mediated Gene Transfer for Treatment of Hemophilia
Current Gene Therapy The Autism Candidate Gene Neurobeachin Encodes a Scaffolding Protein Implicated in Membrane Trafficking and Signaling
Current Molecular Medicine Anticancer Drug Design Using Scaffolds of β-Lactams, Sulfonamides, Quinoline, Quinoxaline and Natural Products. Drugs Advances in Clinical Trials
Current Medicinal Chemistry Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme
Current Medicinal Chemistry Pharmacogenetics of Opioids for the Treatment of Acute Maternal Pain During Pregnancy and Lactation
Current Drug Metabolism Toll-Like Receptors in the Cycling Female Reproductive Tract and During Pregnancy
Current Women`s Health Reviews Matching Chelators to Radiometals for Positron Emission Tomography Imaging- Guided Targeted Drug Delivery
Current Drug Targets Hemophagocytic Lymphohistiocytosis (HLH): An Update
Current Immunology Reviews (Discontinued) Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria
Anti-Infective Agents