Exploring the Structural Stability of a Potential Antifungal Peptide Through Computational Analysis

Author(s): R. Rajasekaran, Rao Sethumadhavan

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 11 , 2009


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Abstract:

We analyzed 27 antifungal peptides (AFPs) to understand their stability by various parameters like, stabilization centers, GROMOS, OPLS and FOLDEF force fields. Subsequently, we propose that AFP, NK-Lysin could be considered a potential candidate and also could act as a template for designing the therapeutic peptide drug against pathogenic fungi.

Keywords: NK-Lysin, stabilization centers, total energy, cation-π, intra-molecular interactions, free energy change

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2009
Page: [1386 - 1392]
Pages: 7
DOI: 10.2174/092986609789353637
Price: $65

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