Non-Globular Structures of Tandem Repeats in Proteins

Author(s): Norio Matsushima, Takanori Tanaka, Robert H. Kretsinger

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 11 , 2009

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Abstract:

There are two classes of tandem repeats in proteins - globular and non-globular. There are two subclasses of non-globular repeats. The first, such as collagen, form stable helices. Members of the second are flexible and somewhat disordered both in vitro and in vivo. This review focuses on this second subclass.

Keywords: Tandem repeats, intrinsically unstructured protein, structural change, ligand interaction, rapid evolution, concerted evolution

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2009
Page: [1297 - 1322]
Pages: 26
DOI: 10.2174/092986609789353745
Price: $65

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