Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine

Author(s): Xue-Lin Yang, Dan Liu, Wei Wang, Lei Qu, Yong-Kui Jing, Lin-Xiang Zhao

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 8 , 2009


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Abstract:

Ten artemisinin derivatives containing a piperazine at C-10 linked with ether or ester were designed and synthesized. All the derivatives have improved antiproliferative activity against cancer cell lines, including multidrug resistance (MDR) phenotypes. Compounds linked with ether are more effective than compounds linked with ester.

Keywords: Artemisinin, Synthesis, Leukemia, Growth inhibition, Structure-activity relationship

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2009
Published on: 01 March, 2012
Page: [595 - 598]
Pages: 4
DOI: 10.2174/157018009789353446
Price: $65

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