Crystallographic Cryoenzymology and the Legacy of Tony Fink

Author(s): Gregory A. Petsko

Journal Name: Current Protein & Peptide Science

Volume 10 , Issue 5 , 2009

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During the past thirty years significant contributions to our understanding of the structural origins of the catalytic power of enzymes have come from solution and crystallographic studies of enzyme-substrate and enzymeintermediate complexes trapped at subzero temperatures, a field that was pioneered in large part by Anthony L. Fink and Pierre Douzou. Here I review, from a personal perspective, the history of crystallographic cryoenzymology, with an emphasis on the contributions of Tony Fink. The story has a moral: if you choose your collaborators based not only on their scientific prowess but also on their human qualities, the resulting friendships will enrich your life.

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Article Details

Year: 2009
Page: [416 - 423]
Pages: 8
DOI: 10.2174/138920309789351985
Price: $65

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