Structure-Based Drug Design Strategies in Medicinal Chemistry

Author(s): Adriano D. Andricopulo, Lívia B. Salum, Donald J. Abraham

Journal Name: Current Topics in Medicinal Chemistry

Volume 9 , Issue 9 , 2009

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A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design (SBDD) methods are becoming increasingly powerful, versatile and more widely used. This review summarizes current developments in structure-based virtual screening and receptor-based pharmacophores, highlighting achievements as well as challenges, along with the value of structure-based lead optimization, with emphasis on recent examples of successful applications for the identification of novel active compounds.

Keywords: Structure-based drug design, medicinal chemistry, virtual screening, QSAR, pharmacophores

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Article Details

Year: 2009
Page: [771 - 790]
Pages: 20
DOI: 10.2174/156802609789207127
Price: $65

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