Diastereoselective Addition of Organometallic Reagents to Diimines Derived from (R,R)-1,2-Diaminocyclohexane and Aromatic Aldehydes

Author(s): Diego Savoia, Andrea Gualandi, Marco Bandini

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 6 , 2009


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Abstract:

The double addition of organolithium compounds and allylzinc bromide to the imines prepared from (R,R)-1,2- diaminocyclohexane by condensation with aromatic and heteroaromatic aldehydes gave secondary diamines with high yields and diastereoselectivities apart for the reaction of 2-pyridinealdehyde derivative which occurred with low to moderate stereocontrol.

Keywords: Amine, 1,2-diaminocyclohexane, diastereoselectivity, imine, organometallic reagents

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Article Details

VOLUME: 6
ISSUE: 6
Year: 2009
Page: [434 - 438]
Pages: 5
DOI: 10.2174/157017809789124948
Price: $65

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