QSAR study on N- (Aryl)-4-(Azolylethyl) Thiazole-5-Carboxamides: Novel Potent Inhibitors of VEGF Receptors I and II

Author(s): Asha Patel, C. Karthikeyan, N. S. Hari Narayana Moorthy, Piyush Trivedi

Journal Name: Medicinal Chemistry

Volume 5 , Issue 5 , 2009


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Abstract:

QSAR study on N- (Aryl)-4-(azolylethyl) thiazole-5-carboxamides analogues, which are novel potent inhibitor of VEGF receptor II and I, were performed using topological, electronic and physicochemical descriptors. The results obtained demonstrate in detail, which specify that topological descriptors of the compounds play a significant role in developing QSAR models. The significance of presence and absence of substituents on particular position is successfully explored with the help of indicator variables. The results are critically discussed on the basis of multiple linear regression parameters.

Keywords: QSAR, VEGF receptor, Topological descriptors

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Article Details

VOLUME: 5
ISSUE: 5
Year: 2009
Page: [455 - 461]
Pages: 7
DOI: 10.2174/157340609789117813
Price: $65

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