Abstract
A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by 1HNMR, 13CNMR, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.
Keywords: Derivative, Antitumor, Agent, In vitro, Crystal structure, X-ray crystal analysis
Letters in Drug Design & Discovery
Title: Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative
Volume: 6 Issue: 7
Author(s): Youguang Zheng, Xiaoqing Wu, Min Sun, Liuhai Feng, Mingdong Li and Min Ji
Affiliation:
Keywords: Derivative, Antitumor, Agent, In vitro, Crystal structure, X-ray crystal analysis
Abstract: A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by 1HNMR, 13CNMR, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.
Export Options
About this article
Cite this article as:
Zheng Youguang, Wu Xiaoqing, Sun Min, Feng Liuhai, Li Mingdong and Ji Min, Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108240
DOI https://dx.doi.org/10.2174/157018009789108240 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current Perspectives on Anti-Aging Interventions
Letters in Drug Design & Discovery An Advanced Computational Evaluation for the Most Biologically Active Enantiomers of Chiral Anti-Cancer Agents
Anti-Cancer Agents in Medicinal Chemistry Phytosynthesized Nanoparticles for Effective Cancer Treatment: A Review
Nanoscience & Nanotechnology-Asia Targeting Histone Onco- Modifications Using Plant-Derived Products
Current Drug Targets Breast Cancer: A Review of Risk Factors and New Insights into Treatment
Current Cancer Therapy Reviews Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships
Current Medicinal Chemistry A Functional Proteomic Approach to the Identification and Characterization of Protein Composition in Wheat Leaf
Current Proteomics More Effective DPP4 Inhibitors as Antidiabetics Based on Sitagliptin Applied QSAR and Clinical Methods
Current Computer-Aided Drug Design Nitrogen-Containing Heterocycles as Anticancer Agents: An Overview
Anti-Cancer Agents in Medicinal Chemistry Pharmacological Management Options to Prevent and Reduce Ischemic Hemorrhagic Transformation
Current Drug Targets Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas
Current Drug Discovery Technologies Natural Polymeric Nanoparticles for Brain-Targeting: Implications on Drug and Gene Delivery
Current Pharmaceutical Design Diabetes and Pancreas: Why So Difficult? Potential Mechanisms of Elevated Serum Pancreatic Enzymes
Current Medicinal Chemistry Putative Mechanisms of Viral Transmission and Molecular Dysregulation of Mammary Epithelial Cells by Human Papillomavirus: Implications for Breast Cancer
Current Molecular Medicine Endoradiotherapy with Peptides - Status and Future Development
Current Medicinal Chemistry Macromolecular Drug Targets in Cancer Treatment and Thiosemicarbazides as Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry The Anti-cancer Actions of Vitamin D
Anti-Cancer Agents in Medicinal Chemistry Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review
Mini-Reviews in Medicinal Chemistry Targeting the Ubiquitin-Proteasome Pathway: An Emerging Concept in Cancer Therapy
Current Topics in Medicinal Chemistry The Epigenomic Viewpoint on Cellular Differentiation of Myeloid Progenitor Cells as it Pertains to Leukemogenesis
Current Genomics