Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α)

Author(s): Sabbir Ahmed, Imran Shahid, Kishore K. Bhatti, Wai-Yee Lee, Caroline P. Owen

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 7 , 2009

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We report the synthesis and evaluation of a range of 2-, 3- and 4-substituted derivatives of benzyl imidazole as probes of the active site of the enzyme 17α-hydroxylase/17,20-lyase (P45017α). In conclusion, the positioning and nature of the substituent appears to play an important role in the inhibition of this enzyme complex.

Keywords: Synthesis, Evaluation, Probe, Enzyme, 17α-hydroxylase, 17,20-lyase

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Article Details

Year: 2009
Page: [524 - 530]
Pages: 7
DOI: 10.2174/157018009789108295
Price: $65

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