Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies

Title: Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies

Volume: 6 Issue: 7

Author(s): Raghu Ningegowda, C. V. Kavitha, B. S. Priya, S. L. Gaonkar, M. V. Tejesvi, K. S. Rangappa and S. Nanjunda Swamy

Affiliation:

Keywords: Benzotriazole, N-alkylation, Solvent-free, Microwave irradiation, Antimicrobials

Abstract: To elucidate further our structural activity relation on the chemistry and antimicrobial activity, a series of novel N-alkylated benzotriazole derivatives bearing pharmaceutically important substituted biphenyl and benzyl halides were synthesized. The synthesized compounds were characterized and tested for in vitro antimicrobial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms. The synthesis has been carried out using microwave irradiation method with solvent and without solvent. The obtained results showed high yields. Interestingly, compounds 2a and 2b showed a two fold increased antibacterial activity than the standard drug tested and the compounds 2d and 2e showed potent antifungal activity than the standard drug tested.

Cite this article as:

Ningegowda Raghu, Kavitha V. C., Priya S. B., Gaonkar L. S., Tejesvi V. M., Rangappa S. K. and Swamy Nanjunda S., Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108222