Abstract
Network biology is conceptualized as an interdisciplinary field, lying at the intersection among graph theory, statistical mechanics and biology. Great efforts have been made to promote the concept of network biology and its various applications in life science. In this review, we focus on the modules that are functional entities and building blocks of a complex network. We first introduce the basic concepts and hot spots of network biology, including several network models, general design principles of complex networks in the module point of view, module discovery approaches and the conservation and evolvability of modules. We then present several cases in which the important mechanisms underlying the cellular behavior are revealed in the framework of network, especially, in the concept of module.
Keywords: Network biology, module, network model, module discovery, evolvability
Current Bioinformatics
Title: Modular Organization in a Cell: Concepts and Applications
Volume: 4 Issue: 3
Author(s): Ruolin Yang and Bing Su
Affiliation:
Keywords: Network biology, module, network model, module discovery, evolvability
Abstract: Network biology is conceptualized as an interdisciplinary field, lying at the intersection among graph theory, statistical mechanics and biology. Great efforts have been made to promote the concept of network biology and its various applications in life science. In this review, we focus on the modules that are functional entities and building blocks of a complex network. We first introduce the basic concepts and hot spots of network biology, including several network models, general design principles of complex networks in the module point of view, module discovery approaches and the conservation and evolvability of modules. We then present several cases in which the important mechanisms underlying the cellular behavior are revealed in the framework of network, especially, in the concept of module.
Export Options
About this article
Cite this article as:
Yang Ruolin and Su Bing, Modular Organization in a Cell: Concepts and Applications, Current Bioinformatics 2009; 4 (3) . https://dx.doi.org/10.2174/157489309789071075
DOI https://dx.doi.org/10.2174/157489309789071075 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Three-Dimensional Tissue Models for Drug Discovery and Toxicology
Recent Patents on Biotechnology Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology
Current Molecular Medicine A Review on Novel Breast Cancer Therapies: Photodynamic Therapy and Plant Derived Agent Induced Cell Death Mechanisms
Anti-Cancer Agents in Medicinal Chemistry Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development
Current Drug Targets Type I Interferons: Ancient Peptides with Still Under-Discovered Anti-Cancer Properties
Protein & Peptide Letters Pathobiology and Prevention of Cancer Chemotherapy-Induced Bone Growth Arrest, Bone Loss, and Osteonecrosis
Current Molecular Medicine Liposomes: A Review of Manufacturing Techniques and Targeting Strategies
Current Nanoscience Development of Prodrugs for Enzyme-Mediated, Tumor-Selective Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Review of Selected Patents for Cancer Therapy Targeting Tumor Angiogenesis
Recent Patents on Anti-Cancer Drug Discovery The Efficacy and Mechanism of Proteasome Inhibitors in Solid Tumor Treatment
Recent Patents on Anti-Cancer Drug Discovery Recent Findings on the Application of Toll-like Receptors Agonists in Cancer Therapy
Current Medicinal Chemistry Nucleic Acids Electrotransfer In Vivo: Mechanisms and Practical Aspects
Current Gene Therapy Galectin-9 in Cancer Therapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Folate-Linked Lipid-Based Nanoparticle for Targeted Gene Delivery
Current Drug Delivery CycloSal-Pronucleotides of Brivudine Monophosphate - Highly Active Antiviral Agents
Current Medicinal Chemistry - Anti-Infective Agents Retroviral Protein Transfer: Falling Apart to Make an Impact
Current Gene Therapy Classification of Sarcomas Using Bioinformatics and Molecular Profiling
Current Pharmaceutical Biotechnology Perinatal Gene Transfer to the Liver
Current Pharmaceutical Design Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization
Current Topics in Medicinal Chemistry Color-Coded Fluorescent Protein Imaging of Angiogenesis: The AngioMouse® Models
Current Pharmaceutical Design