Antinociceptive Activity of Lectins from Diocleinae Seeds on Acetic Acid-Induced Writhing Test in Mice

Author(s): Fernanda R. Holanda, Andrelina N. Coelho-de-Sousa, Ana M.S. Assreuy, Jose Henrique Leal-Cardoso, Alana F. Pires, Kyria S. do Nascimento, Cicero S. Teixeira, Benildo S. Cavada, Claudia F. Santos

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 9 , 2009


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Abstract:

Diocleinae lectins administered per oral route in mice inhibited the abdominal constrictions induced by acetic acid. The percentage of the lectins antinociception varied from 61% for Canavalia grandiflora (ConGf) to 20% for Dioclea violacea. ConGf inhibited contortions at all doses tested but not in a dose-dependent manner, involving carbohydrate recognition.

Keywords: Lectins, Diocleinae subtribe, antinociception, Canavalia grandiflora, carbohydrate recognition

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2009
Page: [1088 - 1092]
Pages: 5
DOI: 10.2174/092986609789055304
Price: $65

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