Regulation of Endochondral Ossification by Osteogenic Growth Peptide CTerminal Pentapeptide [OGP(10-14)]

Author(s): Zhixin Chen, Min Chang, Yali Peng, Li Zhao, Yurui Zhan, Lijing Wang, Rui Wang

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 9 , 2009


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Abstract:

In neonatal rat metatarsal organ culture, a bell-shaped dose-related curve in length of mineralized area, increases in the height of proliferative and hypertrophic zones, in the number of hypertrophic chondrocyte and in the amount of Runx2 mRNA, were revealed after treatment with OGP(10-14). We conclude that OGP(10-14) accelerates bone growth.

Keywords: OGP(10-14), Regulation, Endochondral ossification

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2009
Page: [1074 - 1080]
Pages: 7
DOI: 10.2174/092986609789055395
Price: $65

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