Human Prion Protein Helices: Studying Their Stability by Molecular Dynamics Simulations (SUPPLEMENTARY MATERIAL)

Author(s): Susan Costantini, Angelo M. Facchiano

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 9 , 2009


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Abstract:

To study the intrinsic structural properties of three human prion helices and analyse their stability, we conducted molecular dynamics simulations, applied helix propensity predictions and evaluated the energetic contribution of the helical regions to the PrP protein stability. Our results suggest that three helices present different stability and the helix 2 results the least stable.

Keywords: Prion, helix stability, helix propensity, molecular dynamics, helical peptides

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2009
Page: [1057 - 1062]
Pages: 6
DOI: 10.2174/092986609789055313
Price: $65

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