Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics

Author(s): N. Narendra, T. M. Vishwanatha, N. S. Sudarshan, Vommina V. Sureshbabu

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 9 , 2009

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We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked Northogonally protected dipeptidomimetics by the condensation of Nα-Fmoc α-halomethylketones with thiourea and Boc/Z-α-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4- amino thiazole moiety have also been synthesized following the similar protocol.

Keywords: Nα-Fmoc-haloketones, N-Fmoc-4-amino-thiazolyl derivatives, heteroaryl alanine derivatives and dipeptide thiozoles

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Article Details

Year: 2009
Page: [1029 - 1035]
Pages: 7
DOI: 10.2174/092986609789055403
Price: $65

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