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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety

Author(s): Lyubomir T. Vezenkov, Maria G. Georgieva, Dantcho L. Danalev, Tchavdar B. Ivanov and Galya I. Ivanova

Volume 16, Issue 9, 2009

Page: [1024 - 1028] Pages: 5

DOI: 10.2174/092986609789055412

Price: $65

Abstract

New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.

Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH


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