Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety

Author(s): Lyubomir T. Vezenkov, Maria G. Georgieva, Dantcho L. Danalev, Tchavdar B. Ivanov, Galya I. Ivanova

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 9 , 2009


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Abstract:

New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.

Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2009
Page: [1024 - 1028]
Pages: 5
DOI: 10.2174/092986609789055412
Price: $65

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