Abstract
New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.
Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH
Protein & Peptide Letters
Title: Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety
Volume: 16 Issue: 9
Author(s): Lyubomir T. Vezenkov, Maria G. Georgieva, Dantcho L. Danalev, Tchavdar B. Ivanov and Galya I. Ivanova
Affiliation:
Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH
Abstract: New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.
Export Options
About this article
Cite this article as:
Vezenkov T. Lyubomir, Georgieva G. Maria, Danalev L. Dantcho, Ivanov B. Tchavdar and Ivanova I. Galya, Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety, Protein & Peptide Letters 2009; 16 (9) . https://dx.doi.org/10.2174/092986609789055412
DOI https://dx.doi.org/10.2174/092986609789055412 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders
Current Neuropharmacology An Updated Unified Pharmacophore Model of the Benzodiazepine Binding Site on γ-Aminobutyric Acida Receptors: Correlation with Comparative Models
Current Medicinal Chemistry Prioritizing Disease Genes by Using Search Engine Algorithm
Current Bioinformatics Therapeutic Treatment of Alzheimers Disease Using Metal Complexing Agents
Recent Patents on CNS Drug Discovery (Discontinued) The Role of Coagulation in Pulmonary Pathology
Inflammation & Allergy - Drug Targets (Discontinued) Biological Insight, High-Throughput Datasets and the Nature of Neuro-Degenerative Disorders
Current Drug Metabolism Glucocorticoids Involvement in the Control of CNS Excitability
Recent Patents on CNS Drug Discovery (Discontinued) Neuromodulation of Memory Formation and Extinction
Current Neurovascular Research Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain
Mini-Reviews in Medicinal Chemistry Editorial
Current Pediatric Reviews Folate Based Radiopharmaceuticals for Imaging and Therapy of Cancer and Inflammation
Current Pharmaceutical Design Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma
Current Neuropharmacology Folic Acid, Neurodegenerative and Neuropsychiatric Disease
Current Molecular Medicine Necroptosis: Who Knew There were so Many Interesting Ways to Die?
CNS & Neurological Disorders - Drug Targets Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems
Current Medicinal Chemistry Inpatient Care of the HIV Infected Patient in the Highly Active Antiretroviral Therapy (HAART) Era
Current HIV Research Purinergic Signaling and Hippocampal Long-Term Potentiation
Current Neuropharmacology Malaria during Pregnancy: Incidence, Manifestations, Therapy, and Prevention
Current Women`s Health Reviews Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies
Letters in Organic Chemistry Exploiting the Diversity of the Heat-Shock Protein Family for Primary and Secondary Tauopathy Therapeutics
Current Neuropharmacology