Title: Peptoid Analogues of Anoplin Show Antibacterial Activity
VOLUME: 16 ISSUE: 9
Author(s):K. Meinike and P. R. Hansen
Affiliation:IGM-Bioorganic Chemistry, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
Keywords:Anoplin, antibacterial agents, peptoid, solid-phase synthesis
Abstract: We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (HGLLKXIKTLL- NH2). The most active compounds showed MIC-values of 12.5 and 25 μM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 μM and 11 μM against E.coli and S.aureus. However, the selectivity was reversed. Our results indicate that peptoid analogues of anoplin are promising lead structures for developing new antibacterial agents.
