Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research

Author(s): Pauline F. Marx, Chantal J.N. Verkleij, Mercedes Valls Seron, Joost C.M. Meijers

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 10 , 2009

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Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.

Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation

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Article Details

Year: 2009
Page: [1165 - 1173]
Pages: 9
DOI: 10.2174/138955709789055216
Price: $65

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