Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research

Author(s): Pauline F. Marx, Chantal J.N. Verkleij, Mercedes Valls Seron, Joost C.M. Meijers

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 10 , 2009

Become EABM
Become Reviewer

Abstract:

Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.

Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 9
ISSUE: 10
Year: 2009
Page: [1165 - 1173]
Pages: 9
DOI: 10.2174/138955709789055216
Price: $65

Article Metrics

PDF: 6