Factors Modulating Fibrates Response: Therapeutic Implications and Alternative Strategies

Author(s): M. I. Panadero, M. C. Gonzalez, E. Herrera, C. Bocos

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 9 , Issue 3 , 2009

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Peroxisome proliferator-activated receptor alpha (PPAR??) regulates transcription of genes involved both in lipid and glucose metabolism as well as in inflammation. Fibrates are PPARα ligands used to normalize lipid and glucose parameters and exert antiinflammatory effects. In fact, fibrates have already been demonstrated to benefit metabolic syndrome, type 2 diabetes and cardiovascular diseases. This article reviews the mechanism of action and the functional roles of fibrates, emphasizing the factors modulating their capacity to activate PPARα and affecting their effectiveness. These factors may possibly explain the findings obtained in animal studies and clinical trials with fibrates which showed either untoward effects and/or inefficient hypolipidemic action of PPARα activation. We also discuss briefly the natural and synthetic agonists of PPARαwhich are currently being developed and supposedly display greater effectiveness and fewer adverse effects than fibrates.

Keywords: Peroxisome proliferator-activated receptor, fibrates, natural PPAR agonists, synthetic PPAR activators, metabolic syndrome, type 2 diabetes, cardiovascular disease

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Article Details

Year: 2009
Page: [219 - 236]
Pages: 18
DOI: 10.2174/187153009789044356
Price: $65

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