Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Factors Modulating Fibrates Response: Therapeutic Implications and Alternative Strategies

Author(s): M. I. Panadero, M. C. Gonzalez, E. Herrera and C. Bocos

Volume 9, Issue 3, 2009

Page: [219 - 236] Pages: 18

DOI: 10.2174/187153009789044356

Price: $65

Abstract

Peroxisome proliferator-activated receptor alpha (PPAR??) regulates transcription of genes involved both in lipid and glucose metabolism as well as in inflammation. Fibrates are PPARα ligands used to normalize lipid and glucose parameters and exert antiinflammatory effects. In fact, fibrates have already been demonstrated to benefit metabolic syndrome, type 2 diabetes and cardiovascular diseases. This article reviews the mechanism of action and the functional roles of fibrates, emphasizing the factors modulating their capacity to activate PPARα and affecting their effectiveness. These factors may possibly explain the findings obtained in animal studies and clinical trials with fibrates which showed either untoward effects and/or inefficient hypolipidemic action of PPARα activation. We also discuss briefly the natural and synthetic agonists of PPARαwhich are currently being developed and supposedly display greater effectiveness and fewer adverse effects than fibrates.

Keywords: Peroxisome proliferator-activated receptor, fibrates, natural PPAR agonists, synthetic PPAR activators, metabolic syndrome, type 2 diabetes, cardiovascular disease

Next »

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy