Early Features in Frontotemporal Dementia

Author(s): Ana Maria Villamizar Caycedo, Bruce Miller, Joel Kramer, Katya Rascovsky

Journal Name: Current Alzheimer Research

Volume 6 , Issue 4 , 2009

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Frontotemporal dementia is a disorder of paralimbic prefrontal-insular circuitry. The disorder is often sporadic but can be caused by genetic mutations in tau, progranulin, valosin, TDP-43 and CHMP2b. The major clinical manifestations of FTD include addictive behaviors, disinhibition, apathy, overeating and loss of sympathy and empathy for others. Treatment is currently focused around symptoms but disease-modifying therapies seem feasible.

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Article Details

Year: 2009
Page: [337 - 340]
Pages: 4
DOI: 10.2174/156720509788929255
Price: $65

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