Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target

Author(s): A. Klettner, J. Roider.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 9 , 2009

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The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and – Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.

Keywords: VEGF, ranibizumab, lucentis, AMD, pegaptanib, VEGF-trap

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Article Details

Year: 2009
Page: [1127 - 1135]
Pages: 9
DOI: 10.2174/138955709788922665
Price: $65

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