Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships

Author(s): Costas Giaginis, Stamatios Theocharis, Anna Tsantili-Kakoulidou

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 9 , 2009

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The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.

Keywords: PPAR-γ, type II Diabetes, mechanism of action, 3D-QSAR, 2D-QSAR, drug design

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Article Details

Year: 2009
Page: [1075 - 1083]
Pages: 9
DOI: 10.2174/138955709788922601
Price: $65

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