Brown Recluse Spider Venom: Proteomic Analysis and Proposal of a Putative Mechanism of Action

Author(s): Lucilene D. dos Santos, Nathalia B. Dias, Jose Roberto, A. S. Pinto, Mario S. Palma

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 8 , 2009

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Abstract:

Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage to the toxin structures.

Keywords: Proteomic analysis, spider venom, MudPIT, mass spectrometry, mechanism of action

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2009
Page: [933 - 943]
Pages: 11
DOI: 10.2174/092986609788923383
Price: $65

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