Calcium-Independent Membrane Damage by Venom Phospholipases A2

Author(s): A.H.C. de Oliveira, E. A. Aragao, J. M. Sa, L. Chioato, R. Bugs-Bortoleto, R. Ruller, T. L. Ferreira, R. J. Ward

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 8 , 2009

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Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.

Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation

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Article Details

Year: 2009
Page: [877 - 886]
Pages: 10
DOI: 10.2174/092986609788923392
Price: $65

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