Influence of Quaternary Conformation on the Biological Activities of the Asp49-phospholipases A2s from Snake Venoms

Author(s): Angelo J. Magro, Carlos A.H. Fernandes, Juliana I. dos Santos, Marcos R.M. Fontes

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 8 , 2009

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Abstract:

One of the main components of snake venoms are the Asp49-phospholipases A2, also known as svPLA2s. The study of these toxins is a matter of great scientific interest due to their wide variety of biological effects. In this work we present strong evidences found in literature and other aspects which strengthen the importance of quaternary assembly for understanding the activities and molecular evolution of svPLA2s.

Keywords: Phospholipase A2, oligomerization, quaternary conformation, snake venom

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2009
Page: [852 - 859]
Pages: 8
DOI: 10.2174/092986609788923301
Price: $65

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