Isolation, Characterization and Hypoglycemic Activity of an Acid Polysaccharide Isolated from Schisandra chinensis (Turcz.) Baill

Author(s): Xiaoxv Gao, Xianjun Meng, Jihai Li, Haibin Tong

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 5 , 2009

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The crude polysaccharide (SCP) extracted from Schisandra chinensis by hot water extraction and ethanol precipitation, was further fractionated by DEAE-cellulose and Sephacryl S-300 chromatography, giving a polysaccharide fraction named as SCP-BII. The molecular weight of SCP-BII was 23 kDa using HPGPC. Gas chromatography analysis suggested that SCP-BII was composed of rhamnose, arabinose, mannose, galactose, glucose and galacturonic acid with a ratio of 4.7:2.6:0.8:5.6:1:5.6. Pharmaceutical experiments showed SCP-BII administered in alloxan-induced diabetic mice can significantly reduce blood glucose levels and water intake, and increase the body weight of diabetic mice. The results suggest SCP-BII attenuated the diabetes-induced weight loss, polydipsia and hyperglycemia, and these improvements suggest that Schisandra chinensis could be considered as a potential anti-diabetic agent.

Keywords: Schisandra chinensis, polysaccharide, purification, hypoglycemic, alloxan, anti-diabetic agent

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Article Details

Year: 2009
Page: [428 - 433]
Pages: 6
DOI: 10.2174/157017809788681374
Price: $65

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