3-Formylchromone (1), 3-methyl-7-hydroxychromone (2) and Schiff Bases of 3-formylchromone 3-25 have been synthesized and their antibacterial, antifungal and phytotoxic potentials have been evaluated. Thirteen compounds 1- 7, 14, 17-20 and 22 were screened for their antibacterial effects against fourteen Gram positive and sixteen Gram negative bacterial strains using ampicilline as standard drug. Twelve compounds 1-7, 16-18, 21 and 22 were evaluated against fourteen fungal strains. Eighteen compounds 1-4, 6-13, 15, 17, and 23-25 were screened for their phytotoxic potential and showed varying degree of activity. The structures of the synthesized compounds were determined by using spectroscopic techniques including 1H NMR, EIMS, IR and UV. Elemental analysis results were found to be satisfactory.