Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity

Author(s): Yordanka Ivanova, Georgi Momekov, Ognyan Petrov

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 5 , 2009

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The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone, N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone is synthesized and its influence on cytotoxic activity is investigated.

Keywords: Chalcone, 2(3H)-benzoxazolone, Cytotoxicity

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Article Details

Year: 2009
Page: [353 - 357]
Pages: 5
DOI: 10.2174/1570180810906050353
Price: $65

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