Title: Antimicrobial Peptides and Viral Fusion Peptides : How Different They Are?
VOLUME: 16 ISSUE: 7
Author(s):P. Joanne, P. Nicolas and C. El Amri
Affiliation:FRE 2852 Proteines: Biochimie Structurale et Fonctionnelle, Universite Paris 6-CNRS, Peptidome de la peau d'amphibiens, tour 43, 4, Place Jussieu 75252 Paris cedex 05, France.
Keywords:Antimicrobial peptides, Viral fusion peptides, Hydrophobicity, Structural plasticity, GXXXG motif, Membrane disruptive properties
Abstract: Similarly to antimicrobial peptides (AMPs), viral fusion peptides (FPs) are membrane-active peptides. This minireview emphasizes the common properties of AMPs and FPs with a special focus on the intrinsic flexibility and structural adaptability of these peptides that are responsible for different mode of interaction with the membrane bilayers. The potential use of AMPs as multifunctional drugs with both antibacterial and antiviral properties is discussed.
