Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors

Author(s): Nikolaos Athinaios, Athanasios Kazantzis, Kerstin Putzker, Joe Lewis, Emmanuel N. Pitsinos

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 4 , 2009

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Employing a flexible synthetic strategy towards laurenditerpenol, two analogues featuring the 7- oxabicyclo[2.2.1]heptane ring system present in the natural product have been prepared and their ability to inhibit HIF-1 activation has been evaluated. Their weak activity indicates the importance of the cyclohexenol part of the prototype.

Keywords: Furan, Diels-Alder reaction, Olefin cross-metathesis, Natural products

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Article Details

Year: 2009
Page: [269 - 271]
Pages: 3
DOI: 10.2174/157017809788489891
Price: $65

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