Towards Retinoid Therapy for Alzheimers Disease

Author(s): K. Shudo, H. Fukasawa, M. Nakagomi, N. Yamagata

Journal Name: Current Alzheimer Research

Volume 6 , Issue 3 , 2009

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Alzheimers disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

Keywords: Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration

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Article Details

Year: 2009
Page: [302 - 311]
Pages: 10
DOI: 10.2174/156720509788486581

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