Title: Thalidomide Chemotherapy-Induced Peripheral Neuropathy: Actual Status and New Perspectives with Thalidomide Analogues Derivatives
VOLUME: 9 ISSUE: 7
Author(s):Sante Cundari and Guido Cavaletti
Affiliation:Department of Neuroscience and Biomedical Technologies, University of Milan “Bicocca”, Via Cadore 48 - 20052 Monza (MI), Italy.
Keywords:IMiDs, thalidomide, CC-5013, lenalidomide, CC-4047, pomalidomide, safety, side effects, CIPN
Abstract: IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy- Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed.
