Thalidomide Chemotherapy-Induced Peripheral Neuropathy: Actual Status and New Perspectives with Thalidomide Analogues Derivatives

Author(s): Sante Cundari, Guido Cavaletti

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 7 , 2009

Become EABM
Become Reviewer
Call for Editor


IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy- Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed.

Keywords: IMiDs, thalidomide, CC-5013, lenalidomide, CC-4047, pomalidomide, safety, side effects, CIPN

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Page: [760 - 768]
Pages: 9
DOI: 10.2174/138955709788452595
Price: $65

Article Metrics

PDF: 16