RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery

Author(s): Travis W. Day, Ahmad R. Safa

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 6 , 2009

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Abstract:

The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.

Keywords: RNA interference, c-FLIP, apoptosis, apoptotic pathways, drug discovery, cancer, caspases

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2009
Page: [741 - 748]
Pages: 8
DOI: 10.2174/138955709788452748
Price: $65

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